Fine was a long time member of the important American Abstract Artists group (AAA). Her education began in her native Boston before she enrolled at the Art Students League in 1935 and fell under the influence of Piet Mondrian. In 1939, she began working with Hans Hofmann, both in New York and at his summer school in Provincetown, MA. Fine broke with Hofmann's theories and sought to find her own, more calm and contemplative mode of expression. After 1970 she focused her efforts on a series of spare, elegant geometric works called Accordments.

Fine remained active in the arts throughout her life, teaching at Cornell University and Hofstra University. She had more than 30 solo exhibitions and countless group showings and is represented in numerous museum and private collections. A museum retrospective and catalog is planned for 2009 at Hofstra University with a traveling exhibition and numerous lectures and workshops.